Research Consortia

Insilico Biotechnology is a partner in the following joint research projects:

Chiramet

Insilico partners in the joint research project Chiramet ("Custom-tailored ingredients - Joint project - Chiral building blocks produced from the biomass conversion product methanol", subproject D). Chiramet is funded by the German Ministry for Education and Research (Bundesministerium für Bildung und Forschung, BMBF). Insilico delivers computational models and simulations of the organism Methylobacterium extorquens for strain design and optimization of the production process of chiral building blocks from the biomass conversion product methanol. Link

HiPSTAR

Insilico is partner of the joint research project HiPSTAR ("Human iPS Cell-based Blood-Brain Barrier Technology in Alzheimer Research") to investigate neurodegenerative aspects of Alzheimer's disease. HiPSTAR is funded by the German Ministry for Education and Research (Bundesministerium für Bildung und Forschung, BMBF). In HiPSTAR Insilico will develop a computational model for cells forming the blood-brain-barrier. Link (german)

SyMBioSys

Thirteen organizations from industry and academia collaborate to form the international SyMBioSys ("Systematic Models for Biological Systems Engineering Training Network") training initiative to support a new generation of capable early stage researchers involved in developing mathematical computational models for biomedical and biological systems engineering. SyMBioSys is funded by the Horizon 2020 Framework Programme of the European Union. One of these early stage researchers works on her PhD with Insilico. Link

Biopredyn

The aim of BioPreDyn is to develop new computational tools for integrating and analysing the vast amounts of data which must be handled in the fields of biology and biotechnology, with the overall goal of improving biotechnological processes and applications. Link

COSMOS

COSMOS is a sub-project of the SEURAT European research initiative (Safety Evaluation Ultimately Replacing Animal Testing) out to provide the cosmetic industry with non-animal safety tests for its products. The main aim of COSMOS is to develop computational tools and workflows to predict how safe it is to use individual cosmetic ingredients. Link

Dr. Jekyll and Mr. Hyde

As part of the 'Medical Systems Biology' initiative funded by BMBF (Federal Ministry of Education and Research), this interdisciplinary project focuses on key mechanisms leading to the protection of a host by preventing the pathogenic state of Candida albicans. Link

GenBioCom

The main objective of the GenBioCom joint project is to analyse and utilise the potential of actinomycetes and related organism groups for the production of novel optimised drug substances. Link

Genome reduction

This joint project focuses on the optimisation of production strains taking genome reduction in Corynebacterium glutamicum as an example. Link

NOTOX

NOTOX is a sub-project belonging to the SEURAT European research initiative. In order to find alternatives for in vivo testing, NOTOX focuses on predicting long-term toxic effects using computer models based on the systems characterisation of organotypic cultures. Link

OxiSys

OxiSys focuses on the development of experimental data-based mathematical models which can describe the role oxidative injury plays in ageing of cells and organs, and which can be used to simulate and predict ageing processes in the human organism. Link

PROMYSE

With the aim of exploiting methanol as a raw material for biotechnological production, PROMYSE focuses on the computational modelling of metabolic pathways associated with methylotrophy. Link

SysEnCor

SysEnCor focuses on the systems biological characterisation of the energy budget of Corynebacterium glutamicum in order to create genetically optimised production strains with improved energy consumption/productivity ratios. Link

Virtual Liver

The main aim of the Virtual Liver research network is to develop a dynamic mathematical model of the human liver. By integrating quantitative experimental data, the model will be able to represent human liver physiology, morphology and function from subcellular to whole-organ scale. Link